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  • Title: GI manifestations of Ehlers-Danlos syndrome.
    Author: Solomon JA, Abrams L, Lichtenstein GR.
    Journal: Am J Gastroenterol; 1996 Nov; 91(11):2282-8. PubMed ID: 8931403.
    Abstract:
    Ehlers-Danlos syndrome (EDS) is an inherited disorder of connective tissue that is distinguished not only by the triad of skin hyperextensibility, articular hypermobility, and tissue fragility but also by its heterogeneity on clinical, genetic, and biochemical grounds. The phenotypical variance that characterizes this syndrome often makes its recognition difficult, and failure to recognize the disease despite a classic course is not uncommon. Diagnosis is paramount, however, so life-threatening associations can be searched for and unique principles of management can be instituted. Patients are prone to GI catastrophes such as perforation and massive bleeding, which can be compounded by grave surgical and vascular complications. A thorough knowledge of the GI manifestations of EDS and their management is mandatory to prevent unnecessary morbidity and mortality.
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