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  • Title: Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp. C39217-R109-7. I. Taxonomy of producing organism, fermentation and biological activity.
    Author: Lam KS, Hesler GA, Gustavson DR, Berry RL, Tomita K, MacBeth JL, Ross J, Miller D, Forenza S.
    Journal: J Antibiot (Tokyo); 1996 Sep; 49(9):860-4. PubMed ID: 8931718.
    Abstract:
    Strain C39217-R109-7 (ATCC 53791) is an actinomycete strain isolated from a soil sample collected at Puerto Viejo, Peru. It produces a new antitumor antibiotic, designated pyrrolosporin A. Taxonomic studies on its morphological, cultural and physiological characteristics identified this producing strain as Micromonospora sp. C39217-R109-7. Pyrrolosporin A shows antimicrobial activity against Gram-positive bacteria and it is weakly active against Gram-negative bacteria. Pyrrolosporin A prolongs the life span of mice inoculated with P388 leukemia cells.
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