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  • Title: Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp. C39217-R109-7. II. Isolation, physico-chemical properties, spectroscopic study and X-ray analysis.
    Author: Schroeder DR, Colson KL, Klohr SE, Lee MS, Matson JA, Brinen LS, Clardy J.
    Journal: J Antibiot (Tokyo); 1996 Sep; 49(9):865-72. PubMed ID: 8931719.
    Abstract:
    Pyrrolosporin A (1) is a new macrolide antitumor antibiotic possessing an unusual spiro-alpha-acyltetronic acid moiety. The antibiotic was isolated from the fermentation broth of Micromonospora sp. by vacuum liquid chromatography, crystallization and reversed phase HPLC (C18). The structure was determined by a combination of NMR, MS, IR, UV, X-ray analysis and degradation studies.
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