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  • Title: Synthesis and biological activity of a conformationally constrained chemotactic gamma-lactam formyl tetrapeptide.
    Author: Cavicchioni G, Breveglieri A, Reali E, Spisani S.
    Journal: Arzneimittelforschung; 1996 Oct; 46(10):964-6. PubMed ID: 8931889.
    Abstract:
    The synthesis and biological activity on human neutrophils of for-Met-(gamma-lactam)-Leu-Phe-OMe [fM(gamma l)LP-OMe], an analogue of the chemotactic fMLP-OMe, are reported. The tetrapeptide evidences chemotactic activity as well as superoxide anion production and lysozyme release, although with lower efficacy when compared with the parent tripeptide.
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