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  • Title: Inhibition of human eosinophil chemotaxis in vitro by the anti-allergic agent emedastine difumarate.
    Author: el-Shazly AE, Masuyama K, Samejima Y, Eura M, Ishikawa T.
    Journal: Immunopharmacol Immunotoxicol; 1996 Nov; 18(4):587-95. PubMed ID: 8933171.
    Abstract:
    Emedastine difumarate (emedastine), an anti-allergic agent with anti-histaminic properties, was studied for its effect on human eosinophil chemotaxis induced by platelet activating factor (PAF). Peripheral blood eosinophils (98% purity) were obtained from healthy donors and chemotaxis assay were performed in microchemotaxis chambers. Emedastine showed a significant inhibitory effect on 10(-6) M PAF-induced eosinophil chemotaxis, in dose dependent fashion, at concentrations from 10(-6) to 10(-8) M. Conversely, no inhibitory effect was observed on human neutrophil chemotaxis. Pretreatment of eosinophils with Pyrilamine did not affect PAF-induced eosinophil chemotaxis. Thus emedastine appears to possess a potent and selective inhibitory effect on eosinophils chemotaxis, an action which is probably unrelated to its anti-histamine properties.
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