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  • Title: A double-blind comparison of nafarelin and leuprolide acetate for down-regulation in IVF cycles.
    Author: Corson SL, Gutmann JN, Batzer FR, Gocial B.
    Journal: Int J Fertil Menopausal Stud; 1996; 41(5):446-9. PubMed ID: 8934250.
    Abstract:
    OBJECTIVE: To compare nafarelin (NAF) with leuprolide acetate (LA) for pituitary down-regulation in IVF cycles. MATERIALS AND METHODS: Patients in a private IVF program who received both nasal spray and subcutaneous injections starting in the luteal phase prior to intended stimulation with any one route containing active drug in a randomized, prospective, double-blind study. Variables measured included the usual hormonal values as well as oocyte data, but not pregnancy rates, because of sample size and the heterogeneity of the study group. RESULTS: There were no differences between the two groups in the areas studied. CONCLUSION: Either NAF or LA can be used satisfactorily as an agent for pituitary down-regulation in IVF cycles.
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