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  • Title: Cooperation of ATP and norepinephrine in inducing contraction in guinea pig vas deferens is not associated with change in intracellular Ca2+ level.
    Author: Fujita A, Takeuchi T, Ishii T, Nishio H, Hata F.
    Journal: Jpn J Pharmacol; 1996 Mar; 70(3):273-6. PubMed ID: 8935722.
    Abstract:
    Contractile responses and fura-2 fluorescence signals were simultaneously recorded in fura-2 loaded longitudinal muscle strips of guinea pig vas deferens to examine the relationship between cooperation of ATP and norepinephrine (NE) in the contractile response and intracellular Ca2+ level. ATP or NE induced a rapid or delayed contraction, respectively, with concomitant changes in fura-2 signal. Addition of both agonists potentiated the rapid, but not delayed contraction, while there was no potentiation in the fura-2 signal. In another series of experiments, NE (> or = 10 microM) contracted the muscle without further concomitant increase in Ca2+ level, indicating "Ca2+ sensitization" of the contractile apparatus. These findings suggest that cooperation of ATP and NE in inducing a rapid contraction of guinea pig vas deferens is mainly due to the "Ca2+ sensitization" effect of NE.
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