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  • Title: Receptors for laminins during epithelial morphogenesis.
    Author: Ekblom P.
    Journal: Curr Opin Cell Biol; 1996 Oct; 8(5):700-6. PubMed ID: 8939658.
    Abstract:
    Laminin-1 is expressed by many embryonic epithelial cell types. It binds to receptors on the epithelial cell surface. The integrin alpha6beta1 is a well known laminin-1 receptor that is expressed on many embryonic epithelial cells. More recently, dystroglycan was discovered as a high-affinity receptor for laminin-1 and laminin-2. It is expressed not only by muscle cells but also by embryonic epithelial cells. In embryonic epithelia, dystroglycan may act by binding to the E3 fragment of laminin-1. Integrins and the dystroglycan complex seems to be important for epithelial morphogenesis, but the relative roles of these two receptor systems for epithelial cells are still unclear.
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