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  • Title: Patterns of meiotic double-strand breakage on native and artificial yeast chromosomes.
    Author: Klein S, Zenvirth D, Dror V, Barton AB, Kaback DB, Simchen G.
    Journal: Chromosoma; 1996 Dec; 105(5):276-84. PubMed ID: 8939820.
    Abstract:
    The preferred positions for meiotic double-strand breakage were mapped on Saccharomyces cerevisiae chromosomes I and VI, and on a number of yeast artificial chromosomes carrying human DNA inserts. Each chromosome had strong and weak double-strand break (DSB) sites. On average one DSB-prone region was detected by pulsed-field gel electrophoresis per 25 kb of DNA, but each chromosome had a unique distribution of DSB sites. There were no preferred meiotic DSB sites near the telomeres. DSB-prone regions were associated with all of the known "hot spots" for meiotic recombination on chromosomes I, III and VI.
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