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  • Title: Sex-specific assembly of a dosage compensation complex on the nematode X chromosome.
    Author: Chuang PT, Lieb JD, Meyer BJ.
    Journal: Science; 1996 Dec 06; 274(5293):1736-9. PubMed ID: 8939870.
    Abstract:
    In nematodes, flies, and mammals, dosage compensation equalizes X-chromosome gene expression between the sexes through chromosome-wide regulatory mechanisms that function in one sex to adjust the levels of X-linked transcripts. Here, a dosage compensation complex was identified in the nematode Caenorhabditis elegans that reduces transcript levels from the two X chromosomes in hermaphrodites. This complex contains at least four proteins, including products of the dosage compensation genes dpy-26 and dpy-27. Specific localization of the complex to the hermaphrodite X chromosomes is conferred by XX-specific regulatory genes that coordinately control both sex determination and dosage compensation.
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