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  • Title: [Cytokines in surgical stress].
    Author: Endo S, Inada K, Sato N, Kawamura T.
    Journal: Nihon Geka Gakkai Zasshi; 1996 Sep; 97(9):708-15. PubMed ID: 8940680.
    Abstract:
    The systemic inflammatory response is seen in association with various clinical conditions. Tumor necrosis factor, or other cytokines play an important role in systemic inflammatory response syndrome (SIRS). A frequent complication of SIRS is the development of organ system dysfunction, such as ARDS, DIC, renal failure, shock, and multiple organ dysfunction. Inflammatory cytokines become a trigger for the production of phospholipase A2, eicosnoids, NO, endothelin-1, thrombomodulin, polymorphonuclear leukocyte, and adhesion molecules. These mediators cause complex pathophysiologic condition in SIRS. In this study, we discuss a role of cytokines in surgical stress, hemorrhagic shock, burns, and septic shock.
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