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  • Title: Is delayed surgery really better for congenital diaphragmatic hernia?: a prospective randomized clinical trial.
    Author: de la Hunt MN, Madden N, Scott JE, Matthews JN, Beck J, Sadler C, Barrett AM, Boddy SA, Bray RJ, Cusick E, Gardner L, Hargrave SA, Hinton W, Rangecroft L, Spicer R, Stafford M, Thomas D, Vallis CJ, Wagget J.
    Journal: J Pediatr Surg; 1996 Nov; 31(11):1554-6. PubMed ID: 8943121.
    Abstract:
    Delayed surgery has become widely accepted in the management of congenital diaphragmatic hernia after comparing outcomes only with historical retrospective controls. It was the aim of this study to compare early and delayed hernia repair in a randomized prospective clinical trial. Fifty-four infants were randomized to receive either early repair (within 4 hours of admission) or delayed repair (more than 24 hours after birth). The survival rate was higher for the delayed group (57% v 46%), but the difference was not significant (difference: -11; 95% confidence limits: -37.5, 15.5). There were no significant differences between the two groups with respect to length of hospital stay, ventilator dependency, or survival time. Recorded preoperative risk factors were similar for the two groups. Eight infants in the delayed repair group died without having undergone surgery. The optimum time for surgery still needs clarification.
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