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  • Title: Syndrome of inappropriate antidiuretic hormone secretion in neonates with pneumothorax or atelectasis.
    Author: Paxson CL, Stoerner JW, Denson SE, Adcock EW, Morriss FH.
    Journal: J Pediatr; 1977 Sep; 91(3):459-63. PubMed ID: 894420.
    Abstract:
    Nine episodes of the syndrome of inappropriate antidiuretic hormone secretion occurred in five newborn infants following atelectasis or pneumothorax. All infants had pre-existing lung disease and were being treated with positive pressure ventilation. The mean interval between acute atelectasis or pneumothorax and the development of diagnostic hyponatremia, hypo-osmolal serum, hyperosmolal urine, and oliguria was 13.4 hours. Fluid restriction and removal of the triggering event resulted in resolution of the abnormalities within 1.5 to 4 days. Infants who develop atelectasis or pneumothorax should be evaluated for the subsequent occurrence of SIADH; the administration of a water load to them may result in dilutional hyponatremia, for which fluid restriction, not sodium infusion, is the proper therapy.
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