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  • Title: Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction.
    Author: Wiertz EJ, Tortorella D, Bogyo M, Yu J, Mothes W, Jones TR, Rapoport TA, Ploegh HL.
    Journal: Nature; 1996 Dec 05; 384(6608):432-8. PubMed ID: 8945469.
    Abstract:
    The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The human cytomegalovirus gene US2 specifies a product capable of dislocating MHC class I molecules from the endoplasmic reticulum to the cytosol and delivering them to the proteasome. This process involves the Sec61 complex, in what appears to be a reversal of the reaction by which it translocates nascent chains into the endoplasmic reticulum.
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