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  • Title: Oxidative hypothesis of atherogenesis.
    Author: Klatt P, Esterbauer H.
    Journal: J Cardiovasc Risk; 1996 Aug; 3(4):346-51. PubMed ID: 8946263.
    Abstract:
    The oxidative hypothesis of atherogenesis suggests that an important event in the development of atherosclerotic lesions is the oxidation of lipids contained in low-density lipoprotein (LDL). This hypothesis is supported by a number of in-vitro and in-vivo studies demonstrating the proatherogenic properties of oxidized LDL, the occurrence of oxidatively modified LDL in atherosclerotic lesions and the reduction of atherosclerotic events by antioxidants.
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