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  • Title: Cytotoxic triterpenes from a marine sponge, Stelletta sp.
    Author: McCormick JL, McKee TC, Cardellina JH, Leid M, Boyd MR.
    Journal: J Nat Prod; 1996 Nov; 59(11):1047-50. PubMed ID: 8946745.
    Abstract:
    Bioassay-guided fractionation of an extract of a marine sponge, Stelletta sp., has led to the isolation and characterization of four new cytotoxic isomalabaricane triterpenes, named stellettins C (1), D (2), E (3), and F (4). Three known triterpenes (5-7) were also isolated from the same extract. The most sensitive of the tested cell lines (e.g., leukemia, central nervous system, renal) generally responded with GI50 concentrations in the low-to-mid nanomolar range.
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