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  • Title: Synthesis and antiallergic activity of 2-hydroxy-3-nitro-1,4-naphthoquinones.
    Author: Buckle DR, Cantello BC, Smith H, Smith RJ, Spicer BA.
    Journal: J Med Chem; 1977 Aug; 20(8):1059-64. PubMed ID: 894675.
    Abstract:
    A selection of novel 2-hydroxy-3-nitro-1,4-naphthoquinones are shown to be potent inhibitors of rat passive cutaneous anaphylaxis (PCA) and to have highest potency with alkyl substitution at both C-6 and C-7. The most potent compounds were 7c and 7e which produced a 50% inhibition in the rat PCA test at doses of about 10 micrometerM/kg following subcutaneous administration and showed activity after oral administration. Related 4-hydroxy-3-nitro-2(1H)-naphthalenones had no effect on rat PCA in doses up to 500 micrometerM/kg.
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