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  • Title: Intracellular glutathione as a possible direct blocker of HIV type 1 reverse transcription.
    Author: Kameoka M, Okada Y, Tobiume M, Kimura T, Ikuta K.
    Journal: AIDS Res Hum Retroviruses; 1996 Nov 20; 12(17):1635-8. PubMed ID: 8947299.
    Abstract:
    In AIDS patients, chronic inflammation and elevated levels of cytokines seem to be associated with reduced levels of glutathione (GSH). GSH has been proposed to inhibit the activation of NF-kB, which results in the inhibition of HIV-1 replication. Here, we show the evidence that GSH and N-acetylcysteine, but not L-cysteine or dithiothreitol, could inhibit the reverse transcriptase (RT) process of HIV-1. Such inhibition was not observed with the RT of murine leukemia virus.
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