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  • Title: The activation of K-ras gene at an early stage of lung tumorigenesis in mice.
    Author: Ichikawa T, Yano Y, Uchida M, Otani S, Hagiwara K, Yano T.
    Journal: Cancer Lett; 1996 Oct 22; 107(2):165-70. PubMed ID: 8947508.
    Abstract:
    To clarify the exact timing of K-ras gene mutational activation in lung tumorigenesis of mice, we applied a sensitive mutant allele specific amplification (MASA) method to pulmonary DNA from urethane-treated mice. The activation of K-ras gene with 61st codon AT mutation was detected in the lungs of mice at day 14 but not day 7 after urethane treatment by MASA. The mutation of MASA products was also checked by XbaI restriction fragment length polymorphism analysis and DNA sequencing. These data suggest that the mutation of K-ras gene in the lungs of mice treated with urethane occurred at the early stage of lung tumorigenesis.
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