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  • Title: [The general pharmacological actions of KW-1062, a new aminoglycoside antibiotic (author's transl)].
    Author: Hashimoto T, Ichikawa S, Kojima T.
    Journal: Jpn J Antibiot; 1977 Jun; 30(6):362-85. PubMed ID: 894835.
    Abstract:
    The general pharmacological actions of KW-1062 were investigated in order to estimate the effects on the host animals. KW-1062 showed little or no effect on the central nervous system, cardiovascular system, smooth muscle, skeletal muscle, hemolysis, blood coagulation, dermal tissue permeability and antigenicity tests at high doses. KW-1062 showed urinative effect and ototoxicity. But ototoxicity of KW-1062 was less potent than that of gentamicin. KW-1062 has been proved to have a safety margin wider than that of other aminoglycoside antibiotics.
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