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  • Title: Thromboxane A2 stimulates mitogen-activated protein kinase and arachidonic acid liberation in rabbit platelets.
    Author: Ohkubo S, Nakahata N, Ohizumi Y.
    Journal: Prostaglandins; 1996 Nov; 52(5):403-13. PubMed ID: 8948507.
    Abstract:
    U46619, a thromboxane A2 mimetic, caused tyrosine phosphorylation of several proteins in rabbit platelets. Among them, 42 kDa protein was identified as a mitogen-activated protein kinase (MAPK). U46619 activated MAPK in a concentration-dependent manner, measured by incorporation of 32P to a specific substrate for MAPK. U46619 also liberated [3H] arachidonic acid in a concentration-dependent manner. The U46619-induced MAPK activation and [3H]arachidonic acid liberation were inhibited by SQ29548 and by the removal of external Ca2+ ions. This is a first demonstration that TXA2 activates MAPK accompanied with arachidonic acid liberation in rabbit platelets.
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