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  • Title: Treatment of agnogenic myeloid metaplasia with danazol: a report of four cases.
    Author: Lévy V, Bourgarit A, Delmer A, Legrand O, Baudard M, Rio B, Zittoun R.
    Journal: Am J Hematol; 1996 Dec; 53(4):239-41. PubMed ID: 8948661.
    Abstract:
    Peripheral cytopenias are common in patients with agnogenic myeloid metaplasia (AMM). They are an important cause of morbidity and mortality, and their treatment is difficult. We report on 4 patients with AMM and severe cytopenia treated with danazol (400-600 mg/ day). Three of them became independent of red blood cell (RBC) transfusion, while the other had a slight reduction in RBC requirement. In addition, correction of thrombocytopenia and disappearance of splenomegaly were observed in 1 and 2 patients, respectively. No side effects were observed. In our experience, danazol appears effective and safe in the subset of patients with AMM whose disease is mainly characterized by bone-marrow failure. These data warrant further studies to evaluate this treatment and explore its mechanism of action.
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