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  • Title: Autoantibodies to bullous pemphigoid and epidermolysis bullosa acquisita antigens in an infant.
    Author: Kawachi Y, Ikegami M, Hashimoto T, Matsumura K, Tanaka T, Otsuka F.
    Journal: Br J Dermatol; 1996 Sep; 135(3):443-7. PubMed ID: 8949441.
    Abstract:
    We describe a 1-year-old boy with multiple tense blisters on the skin, who showed circulating autoantibodies directed to both bullous pemphigoid and epidermolysis bullosa acquisita antigens. The patient's serum IgG antibodies bound to the 290-kDa epidermolysis bullosa acquisita antigen with immunoblot analysis of human dermal extracts. Immunoblot analysis also demonstrated that the patient's serum autoantibodies were reactive with recombinant NC16a domain of the 180-kDa bullous pemphigoid antigen. This study confirmed the presence of circulating autoantibodies directed to both bullous pemphigoid antigen and epidermolysis bullosa acquisita antigen.
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