These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The DNA binding affinity of rat liver nucleoproteins to the alpha 1-acid glycoprotein gene.
    Author: Petrović M, Grigorov L, Milosavljević T, Bogojević D.
    Journal: Biochem Mol Biol Int; 1996 Nov; 40(4):741-9. PubMed ID: 8950032.
    Abstract:
    Transcriptional regulation and binding interactions between soluble nucleoproteins and the distal regulatory element (DRE) of the rat alpha 1-acid glycoprotein (alpha 1-AGP) gene were examined in the liver of rats during the acute-phase response. Our results show that the elevation of the alpha1-AGP gene transcription activity in acute phase liver relies basically on an increase in the binding-affinity of the constitutive soluble nucleoproteins with molecular masses 35 and 45 kD, enhancing their capability to bind to the distal regulatory element (DRE) of alpha-AGP gene. On the basis of in vitro phosphorylation/dephosphorylation experiments we discuss that the role of these proteins during alpha 1-AGP transcription may be dependent on their behavior as phosphoproteins. The 35kD nucleoprotein that displayed an acute-phase inducible affinity to bind DRE was identified as a C/EBP beta isoform.
    [Abstract] [Full Text] [Related] [New Search]