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Pubmed for Handhelds

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  • Title: SLE autoantibodies recognize spermine induced Z-conformation of native calf thymus DNA.
    Author: Ali M, Ali A.
    Journal: Biochem Mol Biol Int; 1996 Nov; 40(4):787-97. PubMed ID: 8950037.
    Abstract:
    The binding specificity of naturally occurring anti-DNA antibodies with spermine modified DNA was analyzed by direct binding and competition ELISA. The binding was visualised by band shift assay. The SLE anti-DNA antibodies appreciably recognized the spermine induced Z-conformation of native DNA. The degree of binding of these antibodies to the Z-conformer was almost similar to their binding with native DNA. The spermine-DNA complex was found to be thermodynamically more stable than native DNA.
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