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  • Title: Late reversibility of chronic ifosfamide-associated nephrotoxicity in a child.
    Author: Ashraf MS, Skinner R, English MW, Craft AW, Pearson AD.
    Journal: Med Pediatr Oncol; 1997 Jan; 28(1):62-4. PubMed ID: 8950339.
    Abstract:
    Although reversibility of acute ifosfamide-induced nephrotoxicity is well documented, there is a paucity of data concerning the long-term outcome of chronic renal toxicity, and full recovery from established damage has not been reported. A 4-year-old boy presented with hypophosphatemic rickets 9 months after completion of combination chemotherapy (including ifosfamide) for prostatic rhabdomyosarcoma. Further investigation confirmed glomerular and generalised tubular dysfunction with a Fanconi syndrome. However, serial investigation over the next 4 years revealed complete and sustained recovery of this chronic nephrotoxicity.
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