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  • Title: Fluconazole monotherapy for cryptococcosis in non-AIDS patients.
    Author: Yamaguchi H, Ikemoto H, Watanabe K, Ito A, Hara K, Kohno S.
    Journal: Eur J Clin Microbiol Infect Dis; 1996 Oct; 15(10):787-92. PubMed ID: 8950555.
    Abstract:
    Treatment with 200 to 400 mg/day fluconazole was evaluated in 44 patients without AIDS who had cryptococcosis (19 with cryptococcal meningitis, 22 with pulmonary cryptococcosis, 3 with other cryptococcal infections). For all patients, the clinical response rate was 89% (48% were clinically cured and 41% clinically improved). Of the patients with cryptococcal meningitis, 89% were mycologically cured. These rates are comparable to those obtained in the treatment of AIDS patients with cryptococcal disease. In the group of patients with cryptococcal meningitis, there was a high rate of agreement between the mycological response to therapy and cryptococcal antigen test results. The use of cryptococcal antigen testing is recommended in all patients with cryptococcosis.
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