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  • Title: [The clinical application of long-acting preparations of theophylline].
    Author: Tanaka K.
    Journal: Nihon Rinsho; 1996 Nov; 54(11):3108-12. PubMed ID: 8950963.
    Abstract:
    The advantage of long-acting preparations of theophylline in clinical practice is that they can be used to maintain a stable concentration of the drug in blood for long periods of time. These preparations are also particularly useful in non-compliant patients. In addition, by reducing the circadian variation in the concentration of theophylline in blood they reduce the risk of early morning asthma attacks. In a survey of physicians in private practice, 63% said that theophylline preparations are appropriate as drugs of first choice in treating asthma, and the average of the reported daily doses was 369.5 mg.
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