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  • Title: [Evaluation of the reagent "IL Test LAC Screen/IL Test LAC Confirm" for the biological diagnosis of circulating lupus anticoagulants].
    Author: Magdelaine A, Verdy E.
    Journal: Ann Biol Clin (Paris); 1996; 54(7):293-6. PubMed ID: 8952726.
    Abstract:
    Lupus anticoagulants (LA) are immunoglobulins which interfere with in vitro phospholipid-dependent coagulation tests. Its presence is associated with thromboembolic events. Laboratory recognition of these inhibitors is therefore of increasing clinical importance. A variety of tests has been introduced to detect LAs. In this study, 'IL Test LAC Screen/LAC Confirm', a new sensitive LA test, is evaluated on 23 LA-positive and 70 LA-negative plasmas. In this procedure, a dilute Russell's viper venom is served as a screening test with addition of phospholipids as a confirmatory test. A correct sensitivity for LAs is observed. This new approach for biological LA diagnosis may contribute to an accurate LA recognition in association with one or more phospholipid-dependent coagulation tests.
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