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  • Title: [Value of nucleic acid amplification methods Amplicor (Roche) and Amplified MTD (Gen-Probe) for the rapid diagnosis of tuberculosis].
    Author: Dailloux M, Laurain C.
    Journal: Ann Biol Clin (Paris); 1996; 54(7):297-301. PubMed ID: 8952727.
    Abstract:
    The nucleic acid amplification methods: Amplicor (Roche diagnostic) and AMTD Amplified Mycobacterium tuberculosis Test Direct-(Gen-Probe) were tested in 278 specimens from 231 patients suspect to be affected by mycobacterial infection. When results of both methods: Amplicor and AMTD were compared with culture results (specimens grow M tuberculosis) and clinical characteristics, the sensitivity and specificity were 91.4% and 97.9% respectively for pulmonary specimens and 61.1% and 98.6% respectively for extrapulmonary specimens. Detection of amplification inhibitors reduce false-negative reactions and control of specimen with microscopic negative and amplification positive, reduce the false-positive reactions. Amplicor and AMTD kits can be used in clinical laboratories. Both assays have the potential to reduce the time of tuberculosis diagnosis to one day.
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