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  • Title: [Examination of percutaneous minocycline hydrochloride injection therapy for hepatic cyst by one puncture method].
    Author: Tanaka Y, Ogino M, Tokuda H, Mizuno M, Yamauchi M, Iijima Y, Hattori K, Kato T, Komatsubara Y, Kato H, Hayashi K.
    Journal: Nihon Shokakibyo Gakkai Zasshi; 1996 Nov; 93(11):828-36. PubMed ID: 8953923.
    Abstract:
    Minocycline hydrochloride (MINO) at a dose of 500 mg (in principle) was injected into each of 11 hepatic cysts/10 cases (mean maximum diameter: 12.6 cm) that exhibited symptoms or a tendency toward growth by percutaneous transhepatic one puncture method, and the relation between therapeutic efficacy and pH of cystic fluid was examined. The efficacy was evaluated by abdominal CT after 3 months, and when a shrink of 50% or more in the maximum diameter was observed, it was judged as marked response. Marked effect was observed in 9 lesions of 11 (82%). This MINO injection therapy by one puncture method is very safe, simple and useful. Reduction in intra-cystic pH was not always related to the therapeutic efficacy, so involvement of cytotoxicity of MINO was suggested in degenerating the cystic epithelial cells.
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