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  • Title: Aldosterone-producing adenomas do not contain glucocorticoid-remediable aldosteronism chimeric gene duplications.
    Author: Carroll J, Dluhy R, Fallo F, Pistorello M, Bradwin G, Gomez-Sanchez CE, Mortensen R.
    Journal: J Clin Endocrinol Metab; 1996 Dec; 81(12):4310-2. PubMed ID: 8954032.
    Abstract:
    In glucocorticoid-remediable aldosteronism (GRA) a chimeric gene has been described with the activity of aldosterone synthase, but the promoter of 11 beta-hydroxylase leading to ectopic expression of aldosterone synthase activity in the zona fasciculata. Similar to GRA, in aldosterone-producing adenomas (APA), the primary regulation of aldosterone production is ACTH, and there is increased production of the 18-oxygenated cortisol compounds, 18-oxocortisol and 18-hydroxycortisol. Because of these hormonal similarities, we tested whether a chimeric GRA-like gene was present in APA from 11 patients. A GRA-like chimeric gene was not found in the DNA from these tumors and, therefore, is not the mechanism responsible for hyperaldosteronism in APA.
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