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  • Title: Molecular cloning and expression of a novel peptide (LN1) gene: reduced expression in the renal cortex of lupus nephritis in MRL/lpr mouse.
    Author: Iwano M, Ueno S, Miyazaki M, Harada T, Nagai Y, Hirano M, Dohi Y, Akai Y, Kurioka H, Dohi K.
    Journal: Biochem Biophys Res Commun; 1996 Dec 04; 229(1):355-60. PubMed ID: 8954131.
    Abstract:
    A gene has been identified by mRNA differential display whose expression is reduced in the renal cortex of MRL/lpr mouse. The nucleotide sequence of the cDNA contains an open reading frame that encodes a protein of 338 amino acids (termed LN1). In situ hybridization showed that LN1 mRNA is present in glomeruli, and a 39 kDa protein was detected in the kidney by immunoblot. A human LN1 cDNA was also isolated, the deduced amino acid sequence of which is 78% identical to that of mouse LN1. Although the function of LN1 remains to be elucidated, its reduced expression may contribute to the pathogenesis of lupus nephritis.
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