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  • Title: Autoantibody-associated sensory neuronopathy and intestinal pseudo-obstruction without detectable neoplasia.
    Author: Briellmann RS, Sturzenegger M, Gerber HA, Schaffner T, Hess CW.
    Journal: Eur Neurol; 1996; 36(6):369-73. PubMed ID: 8954305.
    Abstract:
    A 60-year-old patient presenting with the typical features of progressive sensory neuronopathy and subsequent intestinal pseudo-obstruction was found to have antineuronal nuclear antibodies (ANNA-I or Anti-Hu). These findings were suggestive of a paraneoplastic syndrome, but neither clinically nor at autopsy could a neoplasm be detected. Neuropathological findings were identical with those known for carcinoma-associated forms with marked neuron loss of spinal sensory ganglia and myenteric plexus. Therefore, ANNA-I and intestinal pseudo-obstruction may in rare cases occur without detectable underlying cancer.
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