These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Human chorionic gonadotropin induces nitric oxide synthase mRNA in mouse peritoneal macrophages.
    Author: Kim HM, Moon YH.
    Journal: Biochem Biophys Res Commun; 1996 Dec 13; 229(2):548-52. PubMed ID: 8954935.
    Abstract:
    We examined the effects of human chorionic gonadotropin (hCG) on the production of nitric oxide (NO) by mouse peritoneal macrophages. hCG had no effect on NO synthesis by itself, whereas recombinant interferon-gamma (rIFN-gamma) alone had modest activity. When hCG was used in combination with rIFN-gamma, there was a marked cooperative induction of NO synthesis in a dose-dependent manner. The optimal effect of hCG on NO synthesis was shown at 6 h after treatment with rIFN-gamma. This increase in NO synthesis was reflected as increased amount of inducible NO synthase (iNOS) mRNA. NG-monomethyl-L-arginine, and arginase inhibited rIFN-gamma-plus-hCG-induced NO production. On the basis of these observations, we conclude that hCG activates expression of iNOS mRNA in mouse peritoneal macrophages accompanied by NO accumulation via pathway dependent on L-arginine in the culture medium.
    [Abstract] [Full Text] [Related] [New Search]