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  • Title: Plasma 25-hydroxyvitamin D in pregnant Asian women and their babies.
    Author: Heckmatt JZ, Peacock M, Davies AE, McMurray J, Isherwood DM.
    Journal: Lancet; 1979 Sep 15; 2(8142):546-8. PubMed ID: 89556.
    Abstract:
    Plasma 25-hydroxyvitamin D (25-OHD) was measured in cord blood taken at delivery and in fasting blood taken from 44 Asian mothers in the first day of the puerperium. Blood was taken from the baby 48 h after delivery. Cord-blood samples were also taken at 43 non-Asian deliveries. Plasma 25-OHD concentrations in Asians were low at delivery; in 81% of the mothers and 36% of the babies plasma 25-OHD was in the osteomalacic range. Asian lower than concentrations in non-Asian controls. 4 Asian babies had vraniotabes and 1 had neonatal tetany. 1 non-Asian baby had craniotabes. A review of 3327 deliveries in 1978 confirmed that neonatal tetany was significantly more common in Asian babies (2.3%) than in non-Asian babies (0.3%). In 44 other Asian mothers supplements of 1000 units of vitamin D daily during pregnancy significantly increased plasma-25-OHD concentrations at delivery. Asian babies were examined for signs of neonatal rickets, and plasma 25-hydroxyvitamin D (25-OHD) was measured in their mothers. 25-OHD was quantified in cord blood taken at delivery and in fasting blood taken from 44 Asian mothers on the 1st day of puerperium. Babies had blood drawn 48 hours after delivery. Cord-blood samples were also taken from 43 non-Asian deliveries. Plasma 25-OHD levels were low in Asian mothers and babies at delivery. In 81% of the mothers, 68% of cord bloods, and 36% of babies, concentrations were in the osteomalacic range ( 25 nmol/l). Cord-blood 25-OHD in Asians was significantly lower than in non-Asians (P .001); and in only 1/44 non-Asian cord bloods was 25-OHD less than 25 nmol/l. None of the Asian mothers had clinically detectable osteomalacia. A highly significant correlation was found between plasma 25-OHD in mother and cord (P .001), mother and baby (P .001), and cord and baby (P .001). Cord plasma calcium concentrations were significantly lower in Asians than in non-Asians (P .001). There was no relation between 25-OHD and calcium concentrations in maternal or neonatal plasma. 4 Asian babies had craniotabes and 1 had neonatal tetany. 1 non-Asian baby had craniotabes. A review of 3327 deliveries in 1978 confirmed that neonatal tetany was significantly more common in Asian babies (2.3%) than in non-Asian babies (.03%). In 44 other Asian mothers, supplements of 1000 U of vitamin D daily during pregnancy significnatly increased plasma 25-OHD concentrations at delivery.
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