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  • Title: Hypoadrenocorticism in beagles exposed to aerosols of plutonium-238 dioxide by inhalation.
    Author: Weller RE, Buschbom RL, Dagle GE, Park JF, Ragan HA, Watson CR.
    Journal: Radiat Res; 1996 Dec; 146(6):688-93. PubMed ID: 8955720.
    Abstract:
    Hypoadrenocorticism, known as Addison's disease in humans, was diagnosed in six beagles after inhalation of at least 1.7 kBq/g lung of 238PuO2. Histological examination of adrenal gland specimens obtained at necropsy revealed marked adrenal cortical atrophy in all cases. Autoradiographs showed only slight alpha-particle activity. Although the pathogenesis of adrenal cortical atrophy in these dogs is unclear, there is evidence to suggest an autoimmune disorder linked to damage resulting from alpha-particle irradiation to the lymphatic system.
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