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  • Title: Iron therapy resistant microcytic anaemia in a 13-year-old girl with Castleman disease.
    Author: De Heer-Groen TA, Prakken AB, Bax NM, van Dijken PJ.
    Journal: Eur J Pediatr; 1996 Dec; 155(12):1015-7. PubMed ID: 8956935.
    Abstract:
    UNLABELLED: We describe the case history of a 13-year-old girl with chronic fatigue and prolonged microcytic anaemia. She received oral iron since the age of 11 but failed to respond to it. Laboratory studies revealed elevated C-reactive protein and hypergammaglobulinaemia. A large solitary mesenterial lymph node could be demonstrated by ultrasonography and CT. A diagnosis of Castleman disease was suspected and confirmed histologically. After surgical removal of the lymphoma the patient recovered completely. CONCLUSION: Castleman disease should be considered in cases of chronic fatigue, unexplained fever, microcytic anaemia and hypergammaglobulinaemia.
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