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  • Title: Mecamylamine-precipitated nicotine-withdrawal aversion in rats.
    Author: Suzuki T, Ise Y, Tsuda M, Maeda J, Misawa M.
    Journal: Eur J Pharmacol; 1996 Oct 31; 314(3):281-4. PubMed ID: 8957247.
    Abstract:
    The present study examined a rapid and convenient model for evaluating nicotine dependence using the conditioned place preference paradigm. Rats were chronically infused subcutaneously with 9 mg/kg per day nicotine using an osmotic minipump. After nicotine infusion for 7 days, the nicotinic receptor antagonist mecamylamine produced a place aversion in nicotine-dependent rats, but not in acute nicotine-treated rats or sham-operated rats. These results suggest that the mecamylamine-precipitated withdrawal aversion in rats chronically treated with nicotine may result from physical dependence on nicotine, and may be useful for studying the physical dependence on nicotine.
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