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  • Title: Decrease in sigma but no increase in striatal dopamine D4 sites in schizophrenic brains.
    Author: Helmeste DM, Tang SW, Bunney WE, Potkin SG, Jones EG.
    Journal: Eur J Pharmacol; 1996 Oct 31; 314(3):R3-5. PubMed ID: 8957266.
    Abstract:
    [3H]Nemonapride differentially defines sigma and dopamine receptor sites depending upon assay conditions. In post-mortem schizophrenic brain tissues, [3H]nemonapride-labeled sigma receptor binding is decreased compared to match normal controls. No striatal dopamine D4/D4-like receptor differential was observed between the schizophrenic or control tissues, using the [3H]nemonapride minus [3H]raclopride subtraction method.
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