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  • Title: Renal natriuretic effects of atrial natriuretic peptide in dogs with alloxan-induced acute pulmonary edema.
    Author: Levy M, Cernacek P.
    Journal: Clin Invest Med; 1996 Dec; 19(6):435-43. PubMed ID: 8959353.
    Abstract:
    OBJECTIVE: To test the effect of atrial natriuretic peptide (ANF) in dogs with acute pulmonary edema in the absence of urinary sodium retention. ANF is normally a potent natriuretic agent, although this effect is attenuated in generalized edema or acute renal failure. DESIGN: Animal study. SUBJECTS: Twenty-nine dogs. INTERVENTION: Induction of acute pulmonary edema with intravenously administered alloxan and administration of ANF according to five protocols. OUTCOME MEASURES: Natriuretic effect of ANF before and after the induction of pulmonary edema during the protocols. RESULTS: In six control animals, induction of pulmonary edema was associated with diuresis (mean 0.38, standard error of the mean [SEM] 0.003 mL/min before alloxan administration v. mean 0.75, SEM 0.11 mL/min after); natriuresis (mean 60, SEM 8 mumol/min before v. mean 103, SEM 12 mumol/min after); and a decline in blood pressure (mean 114, SEM 7 mm Hg before v. mean 93, SEM 9 mm Hg after) and in the glomerular filtration rate (mean 52, SEM 3.3 mL/min before v. mean 36, SEM 3.7 mL/min after). When isoncotic dextran solution was infused in dogs with pulmonary edema, blood pressure was maintained but the glomerular filtration rate still declined by 42% and there was natriuresis. When the renal arteries were clamped for 5 minutes during the infusion of alloxan, diuresis and natriuresis were prevented, but the glomerular filtration rate still declined, although blood pressure was maintained. ANF administered intravenously during pulmonary edema induced a further significant natriuresis in all experimental protocols. Catalase, administered intravenously as a bolus just before the alloxan infusion, prevented pulmonary edema and the associated renal changes. CONCLUSIONS: Although alloxan appears to be directly nephrotoxic, renal damage caused by this compound does not impair the natriuretic effect of ANF in acute pulmonary edema.
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