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  • Title: C-erb B2 oncoprotein expression. Correlation with the Ki-67 labeling index and AgNOR counts in breast carcinoma on fine needle aspiration cytology.
    Author: Sinha SK, Singh UR, Bhatia A.
    Journal: Acta Cytol; 1996; 40(6):1217-20. PubMed ID: 8960031.
    Abstract:
    OBJECTIVE: To evaluate the expression of C-erb B2 on-coprotein and study its correlation with the Ki-67 labeling index and silver-stained nucleolar organizer region (AgNOR) counts on fine needle aspiration cytology (FNAC) of breast carcinoma. STUDY DESIGN: In a prospective study, FNAC was done on 60 cases of infiltrating ductal carcinoma of the breast. Smears from aspirates were either air dried and methanol fixed for May-Grüwald-Giemsa and silver staining for AgNORs or wet fixed for Papanicolaou and immunocytochemical staining for Ki-67 and C-erb B2. RESULTS: Breast carcinoma showing overexpression of C-erb B2 had higher Ki-67 labeling indexes (mean, 21.43) and higher AgNOR counts (mean, 37.92). A statistically significant correlation (r = .8) was seen between AgNOR counts and the Ki-67 labeling index. CONCLUSION: FNAC proved suitable for studying C-erb B2 oncoprotein expression and the Ki-67 labeling index by immunocytochemistry. These parameters supplement the cytologic diagnosis.
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