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  • Title: Cytokine-mediated communication by keratinocytes and Langerhans cells with dendritic epidermal T cells.
    Author: Takashima A, Bergstresser PR.
    Journal: Semin Immunol; 1996 Dec; 8(6):333-9. PubMed ID: 8961384.
    Abstract:
    Dendritic epidermal T cells (DETC) are skin-specific members of the epithelial gamma delta T-cell family that reside normally in murine epidermis. Recent studies indicate that certain cytokines (e.g. IL-2, IL-7 and IL-15) secreted by neighboring cells promote their residence and regulate their immune function. Conversely, DETC regulate the function of neighboring keratinocytes and Langerhans cells by elaborating other cytokines (e.g. interferon-gamma, keratinocyte growth factor and colony-stimulating factors). This reciprocal interaction represents a unique model of cytokine-mediated intercellular communication by tissue-specific gamma delta T cells with nearby epithelial and antigen presenting cells.
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