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  • Title: Mannose-binding protein genetic polymorphisms in black patients with systemic lupus erythematosus.
    Author: Sullivan KE, Wooten C, Goldman D, Petri M.
    Journal: Arthritis Rheum; 1996 Dec; 39(12):2046-51. PubMed ID: 8961910.
    Abstract:
    OBJECTIVE: To determine whether dysfunctional or deficient mannose-binding protein (MBP) variants are found with increased frequency in black patients with systemic lupus erythematosus (SLE) compared with controls. METHODS: Allele-specific polymerase chain reaction amplification of 4 different polymorphic sites was performed on samples from 92 black SLE patients and 86 geographically matched black controls. RESULTS: Two structural polymorphisms of MBP, associated with low serum levels of MBP, were found with significantly increased frequency in the SLE patient population compared with controls. In contrast, a promoter haplotype associated with particularly high serum levels of MBP was negatively associated with SLE. CONCLUSION: Deficiencies of MBP predispose individuals to SLE.
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