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  • Title: Difference in response of D2 receptor binding between 11C-N-methylspiperone and 11C-raclopride against anesthetics in rhesus monkey brain.
    Author: Kobayashi K, Inoue O, Watanabe Y, Onoe H, Långström B.
    Journal: J Neural Transm Gen Sect; 1995; 100(2):147-51. PubMed ID: 8962684.
    Abstract:
    The effects of anesthesia on dopamine D2 receptor binding in the rhesus monkey brain were examined using positron emission tomography. The bindings of 11C-N-methylspiperone (NMSP) and 11C-raclopride (RAC) were measured under controlled ketamine or isoflurane anesthesia. The binding of 11C-NMSP was significantly lower in the striatum anesthetized with isoflurane than with ketamine. There was a smaller change in the binding of 11C-RAC than of 11C-NMSP. These findings suggest that changes in 11C-NMSP or 11C-RAC binding induced by anesthetics were not due solely to changes in the competition of endogenous dopamine.
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