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  • Title: [The role of thyroid hormones in the regulation of phosphatidic acid, phosphatidylinositol, and polyphosphoinositide synthesis in liver cells].
    Author: Krasil'nikova OA, Babenko NA.
    Journal: Biokhimiia; 1996 Aug; 61(8):1422-31. PubMed ID: 8962917.
    Abstract:
    The effect of thyroxine on total phospholipid, phosphatidic acid, phosphatidylinositol, phosphatidylinositol-4-phosphate and phosphatidylinositol-4,5-bisphosphate synthesis in albino rat hepatocytes, has been studied. It has been found that the hormone enhances the [14C]palmitic acid incorporation into lipids. It has been shown also that phorbol-12-myristate-13-acetate mimicks the effect of thyroxine on lipid synthesis, while exogenous sphingosine abolishes it. Sphingosine causes a significant inhibition of phosphoinositide synthesis in intact liver cells.
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