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  • Title: [Assessment of the formation of antibodies to interferon in patients with juvenile respiratory papillomatosis on interferon therapy].
    Author: Kol'tsov VD, Chireshkin DG, Onufrieva EK, Nurmukhametov RKh, Malinovskaia VV, Ershov FI.
    Journal: Vestn Otorinolaringol; 1996; (4):25-7. PubMed ID: 8966873.
    Abstract:
    Children with juvenile respiratory papillomatosis given alpha 2-INF had antibodies to alpha 2-INF in 67.7% of cases. In children treated with intramuscular recombinant alpha 2-INF (reaferon) alone antibodies to INF occurred in 92.3% of patients. The proportion of such patients fell to 28.5% if the children used recombinant alpha 2-INF as rectal suppositories viferon. The level of the antibodies in 4-48 hours decreased 2 times maximally and returned to the baseline on day 3 since intramuscular injection of alpha 2-INF. It is stated that interferon therapy had a positive effect on juvenile respiratory papillomatosis. Antibodies to INF had no negative effects on the treatment results.
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