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  • Title: A comparison of the effects of propofol-alfentanil versus isoflurane anesthesia on arterial oxygenation during one-lung ventilation.
    Author: Reid CW, Slinger PD, Lenis S.
    Journal: J Cardiothorac Vasc Anesth; 1996 Dec; 10(7):860-3. PubMed ID: 8969391.
    Abstract:
    OBJECTIVE: To determine whether intravenous propofol-alfentanil anesthesia provides superior arterial oxygenation (Pao2) during one-lung ventilation (OLV) compared with isoflurane inhalation anesthesia. DESIGN: A prospective, randomized, cross-over study. SETTING: Tertiary-care university hospital. PARTICIPANTS: Thirty adults having either thoracoscopic pulmonary surgery or esophageal surgery. INTERVENTIONS: Patients received either propofol-alfentanil infusion anesthesia or one minimum alveolar concentration (MAC) of isoflurane during the initial period of two-lung ventilation and the first 30 minutes of OLV and then were switched to the other anesthetic for the duration of OLV. MEASUREMENTS AND MAIN RESULTS: Arterial blood gases and hemodynamics were recorded during two-lung ventilation and after 20 and 30 minutes of OLV with each anesthetic technique. The mean values (+/- SD) for Pao2 during propofol-alfentanil anesthesia after 20 minutes (222 +/- 100) and 30 minutes (228 +/- 102 mmHg) of one-lung ventilation were not significantly different than after 20 minutes (213 +/- 99) or 30 minutes (214 +/- 96 mmHg) of isoflurane; beta error less than 0.1. Mean heart rate was lower during intravenous (78 +/- 15 min) than inhalation (85 +/- 17 min) anesthesia (rho = 0.03). CONCLUSION: This study does not support the theory that total intravenous anesthesia will decrease the risk of hypoxemia during OLV.
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