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  • Title: Primary carcinoid tumor of the kidney with special reference to its histogenesis.
    Author: Takeshima Y, Inai K, Yoneda K.
    Journal: Pathol Int; 1996 Nov; 46(11):894-900. PubMed ID: 8970200.
    Abstract:
    A case of primary carcinoid tumor of the kidney occurring in a 66-year-old woman is reported. The tumor was 10 x 10 x 9 cm in size, solid, yellowish-white in color, and associated with massive hemorrhagic necrosis. Histologically, it was composed of trabecular and anastomosing ribbon-like nests. The tumor cells showed argyrophilicity with the Grimelius stain and cytoplasmic positivity for neuroendocrine markers, (including chromogranin A, neuron-specific enolase, synaptophysin and Leu-7), prostatic acid phosphatase, keratin and vimentin. Numerous cytoplasmic neurosecretory granules were demonstrated ultrastructurally. These histologic and immunohistochemical findings are consistent with the theory that this tumor has a common phenotype with that of carcinoid tumor arising from the hindgut or cloaca.
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