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  • Title: Steroids: theoretical and experimental basis for utilization in prevention of contrast media reactions.
    Author: Lasser EC, Lang J, Sovak M, Kolb W, Lyon S, Hamlin AE.
    Journal: Radiology; 1977 Oct; 125(1):1-9. PubMed ID: 897151.
    Abstract:
    In vitro and in vivo studies were done to examine the effects of methylprednisolone on the adverse reactions induced by contrast media. At very high concentrations, the steroid potentiated the complement-activating effect produced in vitro by iodipamide, but inhibited the immune and nonimmune mechanisms of hemolysis. Rabbits pretreated for 3 days with intramuscular methylprednisolone (at high or low dosages) were significantly protected against an LD47 challenging dose of iodipamide. Those treated once with a low intravenous dose immediately prior to iodipamide challenge were protected to a lesser degree. Rabbits treated once with a very high intravenous dose of steroid evidenced no protection. A hyper-responsive dog was consistently protected against adverse reactions to injected sodium iothalamate by a 3-day steroid pretreatment.
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